ASIA Autoimmune / inflammatory syndrome, induced by adjuvants.
ASIA or Shoenfeld's syndrome: a new autoimmune syndrome? 2010 >>
Major criteria
Exposure to an external stimuli (infection, vaccin, silicone, adjuvant prior to clinical manifestions
Appearance of ons of the clinical manifestions:
myalgia, myositis, of muscular weakness
arthralgia and / of arthirtis
chronical fatigue, non-restful, sleep of sleep disturbances
neurological manifestations (especially those associated with demyelization)
cognitive alterations, loss of memory
fever, dry mouth
removal of the initiating agent induces improvement
typical biopsy of the involved organs
Minor criteria
Appearance of autoantibodies derectes anganist the suspected adjuvant
Other clinical manifestations (e.g. irritable blowl syndome)
Specific HLA (e.g. HLA, DRB1, HLA, DQB1)
Initiation of an autoimmune illness (e.g. multiple sclerosis, systemic sclerosis)